Hydrophilic-impermeable modified polyethylene terephthalate for selective endothelialization

17th World Textile Conference AUTEX 2017 - Shaping the Future of Textiles

Chetouane, D.^1 ; Fafet, J.F.^1 ; Barbet, R.^2 ; Dieval, F.^1

Université de Haute Alsace, ENSISA, Laboratoire de Physique et Mécanique Textiles, 11 rue Alfred Werner, Mulhouse

68093, France^1

Institut de Recherche en Hématologie et Transplantation, 87 avenue d'Altkirch, Mulhouse

68100, France^2

关键词: Alkaline solutions;    Endothelialization;    Functionalizations;    Hydrophilic properties;    Mesenchymal stem cell;    Polyethylene terephthalates (PET);    Spherical structures;    Surface alteration;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/254/6/062003/pdf
DOI  :  10.1088/1757-899X/254/6/062003

来源: IOP

【 摘 要 】

The aim of this study was to create a modified polyethylene terephthalate (PET) responding to vascular implants' requirements, mainly with a surface promoting selective endothelialization. The surface alteration was carried out by hydrophilic functionalization in an alkaline solution with the presence of specific surfactant (TA). The carboxylic groups resulting from this reaction were quantified by colorimetric titration using bleu toluidine O dye (TBO). A single-sided coating process was then optimized to cover the PET surface by micro spherical structures' polymeric layer. This coating provided to the PET surface high impermeability to the water under a pressure of 120 mmHg and enhanced its hydrophilic property. This spherical topography reduced the adhesion of Mesenchymal Stem Cells (MSC) by 37% and inhibited their proliferation after 3 days by 50%. The hydrophilic functionalized PET (PET-TA) surface decreased the MSC adhesion by 50% and promoted HUVEC attachment with a number twice more important than the number of HUVEC adhered onto non treated-PET.