Surface Topographical Modification of Coronary Stent: A Review

International Conference on Innovative Research - ICIR Euroinvent 2017

Tan, C.H.^1,2 ; Muhamad, N.^1,2 ; Abdullah, M.M.A.B.^2,3

School of Manufacturing Engineering, Pauh Putra Main Campus, Universiti Malaysia Perlis, Perlis, Malaysia^1

Center of Excellence Geopolymer and Green Technology, School of Materials Engineering, Universiti Malaysia Perlis, Perlis, Malaysia^2

Faculty of Engineering Technology, Uniciti Alam Campus, Universiti Malaysia Perlis, Perlis, Malaysia^3

关键词: Biomaterial surfaces;    Endothelialization;    In-stent restenosis;    Inflammatory response;    Long-term safety;    Nano-meter scale;    Organic materials;    Topographical modifications;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/209/1/012031/pdf
DOI  :  10.1088/1757-899X/209/1/012031

来源: IOP

【 摘 要 】

Driven by the urge of mediating the inflammatory response from coronary stent implant to improve patency rates of the current coronary stent, concern has been focusing on reducing the risk of in-stent restenosis and thrombosis for long-term safety. Surface modification approach has been found to carry great potential due to the surface is the vital parts that act as a buffer layer between the biomaterial and the organic material like blood and vessel tissues. Nevertheless, manipulating cell response in situ using physical patterning is very complex as the exact mechanism were yet elucidated. Thus, the aim of this review is to summarise the recent efforts on modifying the surface topography of coronary stent at the micro- and nanometer scale with the purpose of inducing rapid in situ endothelialization to regenerate a healthy endothelium layer on biomaterial surface. In particular, a discussion on the surface patterns that have been investigated on cell selective behaviour together with the methods used to generate them are presented. Furthermore, the probable future work involving the surface modification of coronary stent were indicated.