Poly (1,8 Octanediol-co-Citrate) Hydroxyapatite Composite as Antibacterial Biodegradable Bone Screw

4th International Conference on Advanced Materials Science and Technology

Widiyanti, P.^1,2 ; Sholikhah, I.^1 ; Isfandiary, A.^1 ; Hasbiyani, N.A.F.^1 ; Lazuardi, M.B.^1 ; Laksana, R.D.^1

Biomedical Engineering, Faculty of Science and Technology, Universitas Airlangga, C Campus, Jalan Mulyorejo, Surabaya

60115, Indonesia^1

Institute of Tropical Disease, Universitas Airlangga, C Campus, Jalan Mulyorejo, Surabaya

60115, Indonesia^2

关键词: Anti-bacterial activity;    Bone screw;    Composition variation;    Degradation capacity;    Fourier transform infra reds;    Hydroxyapatite composite;    Poly(1 ,8octanediol-co-citrate);    Poly-1,8-octanediol-co-citrate (POC);   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/202/1/012082/pdf
DOI  :  10.1088/1757-899X/202/1/012082

来源: IOP

【 摘 要 】

The high bone fracture rates reaching up to 300-400 cases per month have been treated with surgical procedure of internal fixation. Nevertheless, the commonly used metal screw has shown several weaknesses. Therefore, it is required bone screw of which primary characteristics include being biocompatible, bio-functional, biodegradable, and anticorrosive. The study aimed to synthesize Antibacterial Poly 1,8-Octanediol-co-Citrate (POC) and investigated the effect of chitosan on the antibacterial and compatibility characteristics of POC-HA composite as antibacterial biodegradable bone screw. The characterization were conducted on POC-HA composite to assess its functional cluster, antibacterial activity, cytotoxicity, degradation capacity, and morphology. Pre-polymer POC was composited with 62% nano-HA, followed by post-polymerization treatment. The sample then coated by chitosan with composition variations of 1%, 3%, and 5%. The nano-HA marked with the appearance of phosphate cluster on the wavenumber of 872.17 cm-1and 559.51 cm-1, while the chitosan marked with C=O stretch cluster of esther at 1729 cm-1from Fourier Transform Infra-Red (FTIR) measurement. The best result was obtained with 3% chitosan coating. The POC-HA composites showed bacterial inhibiting ability of 16.92 mm with non-toxic characteristics. These results indicated that chitosan coating Poly 1,8-Octanediol-co-Citrate (POC)-Nano Hydroxyapatite composite is a potential candidate for an antibacterial biodegradable bone screw.