The Effect of Pressure and Temperature on Separation of Free Gadolinium(III) From Gd-DTPA Complex by Nanofiltration-Complexation Method

3rd International Conference on Functional Materials Science 2016

Rahayu, Iman^1 ; Anggraeni, Anni^1 ; Ukun, M.S.S.^1 ; Bahti, Husein H.^1

Departement of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Jl. Raya Bandung Sumedang km. 21, Jatinangor, West Java

45363, Indonesia^1

关键词: Complex compounds;    Contrast agent;    Effect of pressure;    Ion rejection;    Magnetic Resonance Imaging (MRI);    Normal tissue;    Permeation fluxes;    Visual contrast;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/196/1/012040/pdf
DOI  :  10.1088/1757-899X/196/1/012040

来源: IOP

【 摘 要 】

Nowdays, the utilization of rare earth elements has been carried out widely in industry and medicine, one of them is gadolinium in Gd-DTPA complex is used as a contrast agent in a magnetic resonance imaging (MRI) diagnostic to increase the visual contrast between normal tissue and diseased. Although the stability of a given complex may be high enough, the complexation step couldnot have been completed, so there is possible to gadolinium(III) in the complex compound. Therefore, the function of that compounds should be dangerous because of the toxicity of gadolinium(III) in human body. So, it is necessarry to separate free gadolinium(III) from Gd-DTPA complex by nanofiltration-complexation. The method of this study is complexing of Gd2O3with DTPA ligand by reflux and separation of Gd-DTPA complex from gadolinium(III) with a nanofiltration membrane on the variation of pressures(2, 3, 4, 5, 6 bars) and temperature (25, 30, 35, 40 °C) and determined the flux and rejection. The results of this study are the higher of pressures and temperatures, permeation flux are increasing and ion rejections are decreasing and gave the free gadolinium(III) rejection until 86.26%.