Solid state synthesis of chitosan and its unsaturated derivatives for laser microfabrication of 3D scaffolds

2015 Global Conference on Polymer and Composite Materials

材料科学;化学

Akopova, T.A.^1 ; Demina, T.S.^1 ; Bagratashvili, V.N.^2 ; Bardakova, K.N.^2 ; Novikov, M.M.^2 ; Selezneva, I.I.^2 ; Istomin, A.V.^1 ; Svidchenko, E.A.^1 ; Cherkaev, G.V.^1 ; Surin, N.M.^1 ; Timashev, P.S.^2

Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences, 70 Profsoyuznaya Str., Moscow

117393, Russia^1

Institute on Laser and Information Technologies, Russian Academy of Sciences, 2 Pionerskaya Str., Troitsk, Moscow

142190, Russia^2

关键词: Biocompatible scaffolds;    Engineered biomaterials;    Laser micro-fabrication;    Laser stereolithography;    Nuclear Magnetic Resonance (NMR);    Photosensitive materials;    Physical-chemical analysis;    Solid-state synthesis;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/87/1/012079/pdf
DOI  :  10.1088/1757-899X/87/1/012079

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Chitosans with various degrees of deacetylation and molecular weights and their allyl substituted derivatives were obtained through a solvent-free reaction under shear deformation in an extruder. Structure and physical-chemical analysis of the samples were carried out using nuclear magnetic resonance (NMR), ultraviolet (UV) and infrared radiation (IR) spectroscopy. Photosensitive materials based on the synthesized polymers were successfully used for microfabrication of 3D well-defined architectonic structures by laser stereolithography. Study on the metabolic activity of NCTC L929 cultured in the presence of the cured chitosan extracts indicates that the engineered biomaterials could support adhesion, spreading and growth of adherent-dependent cells, and thus could be considered as biocompatible scaffolds.