Fabrication of Chitosan based-Scaffold as Potential Cornea Implant

International Conference on Design and Application of Engineering Materials in conjunction with Seminar Nasional Metalurgi dan Material XI (SENAMM)

材料科学;金属学

Rusdiputra, Satria^1 ; Wibowo, Arie^1^2 ; Tresna Wulan Asri, Lia Amelia^1 ; Purwasasmita, Bambang Sunendar^3

Department of Materials Engineering, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Indonesia^1

Research Center for Nanoscience and Nanotechnology, Institut Teknologi Bandung, Indonesia^2

Department of Engineering Physics, Faculty of Industrial Technology, Institut Teknologi Bandung, Indonesia^3

关键词: Biocompatible scaffolds;    Cornea;    Corneal tissues;    Crosslink agents;    Glutaraldehydes;    Hydrogel scaffolds;    Salt-leaching method;    Solution casting;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/547/1/012062/pdf
DOI  :  10.1088/1757-899X/547/1/012062

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Corneal damage is the second cause of blindness in the world due to limitation of high quality corneal from donor. This condition promote rapid development of biodegradable and biocompatible scaffold for corneal tissue because it can reduce the patient's dependence on the cornea donor. The purpose of this research is to synthesize chitosan-based hydrogel scaffold with glutaraldehyde (GA) as crosslink agent and observe the influence of concentration chitosan and GA to transparency and mechanical properties of the scaffold. Scaffolds were prepared by solution casting combined with salt leaching method. Among all of chitosan-based scaffolds that have been prepared, sample with 6.7% of chitosan and 0.0% of GA possess the highest transparency (85%), while sample with 6.7% of chitosan and 0.3% of GA gave the highest Young's modulus (3.09 MPa). However, sample with 6.7% of chitosan and 0.1% of GA might possess the highest potency as corneal tissue implant because of its transparency fulfill the minimum value of corneal tissue (80%) and its Young's modulus (1.41 MPa) is higher than any chitosan-based scaffold with minimum transparency 80%.