Folate receptor mediated in vivo targeted delivery of human serum albumin coated manganese ferrite magnetic nanoparticles to cancer cells

International Conference on Physical Instrumentation and Advanced Materials

物理学;材料科学

Zaidan, A.^1,2 ; Ilhami, F.^1 ; Fahmi, M.Z.^1,3 ; Purwanto, B.^1,4 ; Kharisma, R.Z.^1

Sekolah Pascasarjana Universitas Airlangga, Kampus B Universitas Airlangga, Jalan Airlangga 4-6, Surabaya, Indonesia^1

Department of Physics, Universitas Airlangga, Kampus C, Universitas Airlangga, Mulyorejo, Surabaya, Indonesia^2

Department of Chemistry, Universitas Airlangga, Kampus C, Universitas Airlangga, Mulyorejo, Surabaya, Indonesia^3

Faculty of Medicine, Universitas Airlangga, Kampus A, Universitas Airlangga, Jalan Mayjen Prof. Dr. Moestopo 47, Surabaya, Indonesia^4

关键词: Biomedical applications;    Human serum albumins;    Magnetic nano-particles;    Manganese ferrite nanoparticles;    Manganese ferrites;    Novel applications;    Solvothermal method;    Structure and morphology;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/853/1/012048/pdf
DOI  :  10.1088/1742-6596/853/1/012048

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Manganese ferrite nanoparticles (MnFe2O4) have received increasing attention due to their remarkable magnetic properties and have been used for various biomedical applications. They have potential applications in magnetic resonance imaging and hyperthermia for cancer. Both novel applications require a delivery system that will allow nanoparticle to move easily and localization of nanoparticle to the target tissue. In our work, we developed human serum albumin coated manganese ferrite magnetic nanoparticles (HSA-MF NPs). The nanoparticles were prepared using solvothermal method and modified with folic acid for targeted delivery. Structure and morphology of manganese ferrite nanoparticle were characterized by X-ray diffraction (XRD) pattern and transmission electron microscopy (TEM). The size of folic acid conjugated HSA-MF NPs (HSA-MF-FA NPs) were studied by dynamic light scattering (DLS). In the in vivo study, we used benzopyrene-induced cancer in mice. We successfully delivered HSA-MF-FA NPs through intravenous tail injection after induction of the tumour. We found that 54% of initial HSA-MF-FA NPs which previously injected localize in the target tissue. While obtained p-value from independent T-test is 0.013 which shows that there is a difference between the control group (HSA-MF NPs) and the treated group (HSA-MF-FA NPs)