Characterization of physicochemical and colloidal properties of hydrogel chitosan-coated iron-oxide nanoparticles for cancer therapy

7th Young Researcher Meeting

Catalano, E.^1 ; Di Benedetto, A.^2

Department of Clinical Molecular Biology (EpiGen), Akershus University Hospital, University of Oslo (UiO), Oslo, Norway^1

Dipartimento di Fisica G. Occhialini, Universita Milano-Bicocca, Milano, Italy^2

关键词: Biomedical applications;    Characteristic properties;    Coprecipitation method;    Fourier transformed infrared spectroscopy;    Iron oxide nanoparticle;    Magnetic nano-particles;    Physico-chemical analysis;    Superparamagnetic iron oxide nanoparticles;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/841/1/012010/pdf
DOI  :  10.1088/1742-6596/841/1/012010

来源: IOP

【 摘 要 】

Superparamagnetic iron oxide nanoparticles have recently been investigated for their potential to kill cancer cells with promising results, owing to their ability to be targeted and heated by magnetic fields. In this study, novel hydrogel, chitosan Fe3O4magnetic nanoparticles were synthesized to induce magnetic hyperthermia, and targeted delivering of chemotherapeutics in the cancer microenvironment. The characteristic properties of synthesized bare and CS-MNPs were analyzed by various analytical methods: X-ray diffraction, Fourier transformed infrared spectroscopy, Scanning electron microscopy and Thermo-gravimetric analysis/differential thermal analysis. Magnetic nanoparticles were successfully synthesized using the co-precipitation method. This synthesis technique resulted in nanoparticles with an average particle size of 16 nm. The pure obtained nanoparticles were then successfully encapsulated with 4-nm-thick chitosan coating. The formation of chitosan on the surface of nanoparticles was confirmed by physicochemical analyses. Heating experiments at safe magnetic field (f = 100 kHz, H =10-20 kA m-1) revealed that the maximum achieved temperature of water stable chitosan-coated nanoparticles (50 mg ml-1) is fully in agreement with cancer therapy and biomedical applications.