Role of magnesium on the biomimetic deposition of calcium phosphate

24th Condensed Matter Days National Conference

Sarma, Bimal K.^1 ; Sarma, Bikash^1

Nanophysics Laboratory, Department of Physics, Gauhati University, Guwahati, Assam

781014, India^1

关键词: Amorphous calcium phosphate;    Biomimetic deposition;    Calcium phosphate nanoparticles;    Dental applications;    Hydroxyapatite (HAp);    Nucleation and growth;    Simulated body fluids;    X-ray diffraction studies;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/765/1/012025/pdf
DOI  :  10.1088/1742-6596/765/1/012025

来源: IOP

【 摘 要 】

Biomimetic depositions of calcium phosphate (CaP) are carried out using simulated body fluid (SBF), calcifying solution and newly developed magnesium containing calcifying solution. Calcium phosphate has a rich phase diagram and is well known for its excellent biocompatibility and bioactivity. The most common phase is hydroxyapatite (HAp), an integral component of human bone and tooth, widely used in orthopedic and dental applications. In addition, calcium phosphate nanoparticles show promise for the targeted drug delivery. The doping of calcium phosphate by magnesium, zinc, strontium etc. can change the protein uptake by CaP nanocrystals. This work describes the role of magnesium on the nucleation and growth of CaP on Ti and its oxide substrates. X-ray diffraction studies confirm formation of HAp nanocrystals which closely resemble the structure of bone apatite when grown using SBF and calcifying solution. It has been observed that magnesium plays crucial role in the nucleation and growth of calcium phosphate. A low magnesium level enhances the crystallinity of HAp while higher magnesium content leads to the formation of amorphous calcium phosphate (ACP) phase. Interestingly, the deposition of ACP phase is rapid when magnesium ion concentration in the solution is 40% of calcium plus magnesium ions concentration. Moreover, high magnesium content alters the morphology of CaP films.