Effects of crystallinity and surface modification of calcium phosphate nanoparticles on the loading and release of tetracycline hydro-chloride

17th IUMRS International Conference in Asia

Zhang, Huaizhi^1,2 ; Yan, Dong^1,2 ; Gedara, Sriyani Menike Korale^3 ; Marakkalage, Sajith Sudeepa Fernando Dingiri^3 ; Methlal, Jothirathna Gamage Kasun^3 ; Han, Ying Chao^1,2 ; Dai, Hong Lian^1,2

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan

430070, China^1

Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan

430070, China^2

Faculty of Applied Sciences, Sabaragamuwa University of Sri Lanka, Belihuloya

70140, Sri Lanka^3

关键词: Acidic environment;    Calcium phosphate nanoparticles;    Controlled drug release;    Disease treatment;    Drug loading capacity;    Poly(acrylic acid );    Precipitation methods;    Surface modification agents;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/182/1/012052/pdf
DOI  :  10.1088/1757-899X/182/1/012052

来源: IOP

【 摘 要 】

The influences of crystallinity and surface modification of calcium phosphate nanoparticles (nCaP) on their drug loading capacity and drug release profile were studied in the present investigation. The CaP nanoparticles with different crystallinity were prepared by precipitation method under different temperatures. CaP nanoparticles with lower crystallinity exhibited higher drug loading capacity. The samples were characterized by XRD, FT-IR, SEM, TEM and BET surface area analyzer respectively. The drug loading capacity of nCaP was evaluated to tetracycline hydro-chloride (TCH). The internalization of TCH loaded nCaP in cancer cell was observed by florescence microscope. nCaP could be stabilized and dispersed in aqueous solution by poly(acrylic acid) surface modification agent, leading to enhanced drug loading capacity. The drug release was conducted in different pH environment and the experimental data proved that nCaP were pH sensitive drug carrier, suggesting that nCaP could achieve the controlled drug release in intracellular acidic environment. Furthermore, nCaP with higher crystallinity showed lower drug release rate than that of lower crystallinity, indicating that the drug release profile could be adjusted by crystallinity of nCaP. nCaP with adjustable drug loading and release properties are promising candidate as drug carrier for disease treatment.