Deformulation of a solid pharmaceutical form using computed tomography and X-ray fluorescence

37th Brazilian Meeting on Nuclear Physics

Oliveira, J.M.^1 ; Balcão, V.M.^2,3 ; Vila, M.M.D.C.^2 ; Aranha, N.^1 ; Yoshida, V.M.H.^2 ; Chaud, M.V.^2 ; Filho, S Mangine^1

LaFINAU - Laboratory of Applied Nuclear Physics, University of Sorocaba, Sorocaba/SP, Brazil^1

LaBNUS - Biomaterials and Nanotechnology Laboratory, I(bs)2 - Intelligent Biosensing and Biomolecule Stabilization Research Group, University of Sorocaba, Sorocaba/SP, Brazil^2

CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal^3

关键词: Analytical studies;    Chemical compositions;    Controlled drug release;    Pharmaceutical formulation;    Physico-chemical analysis;    Silicon Drift Detector;    X ray fluorescence;    X ray fluorescence analysis;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/630/1/012002/pdf
DOI  :  10.1088/1742-6596/630/1/012002

来源: IOP

【 摘 要 】

Deformulation of medicines is of undeniable importance, since it can be utilized both to unravel the chemical composition of the excipients integrating a pharmaceutical formulation of a specific medicine and as an important tool to conduct morphometric studies of the formulation under study. Such strategy may be utilized in analytical studies aiming at quantifying the components of reference drugs, or in the identification of putative counterfeit pharmaceuticals. Deformulation makes use of physicochemical analysis tools to characterize, from the chemical point of view, the components integrating medicine pharmaceutical formulations and from the physical point of view, the morphological part of the pharmaceutical formulation. The techniques of computer tomography (SkyScan 1174 - Bruker microCT) and X-ray fluorescence analyses (using an X-ray source with W-anode from Hammatsu Photonics and Silicon Drift detector from Amptek) were successfully used in performing a process of deformulation of a solid pharmaceutical formulation of tablets, utilized herein as a model medicine for controlled drug release. The analytical methods used in this work, proved their effectiveness for the main goal of this study, which aimed to characterize a pharmaceutical formulation via its deconstruction.