Atmospheric pressure imaging mass spectrometry of drugs with various ablating lasers

18th International School on Condensed Matter Physics: "Challenges of Nanoscale Science: Theory, Materials, Applications"

Moshkunov, K.A.^1 ; Alimpiev, S.S.^1 ; Grechnikov, A.A.^2 ; Nikifirov, S.M.^3 ; Pento, A.V.^1 ; Simanovsky, Ya O^3

General Physics Institute of RAS, Vavilov str. 38, Moscow

119991, Russia^1

Vernadsky Institute of Geochemistry and Analytical Chemistry of RAS, Kosygin str. 19, Moscow

119991, Russia^2

Advanced Energy Technologies, Novaya str. 100, Skolkovo

143025, Russia^3

关键词: Ablated materials;    Femtosecond fiber lasers;    Imaging mass spectrometry;    Mass spectrometric detection;    Power deposition;    Sensitivity values;    Stainless steel substrates;    TOF mass spectrometer;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/558/1/012012/pdf
DOI  :  10.1088/1742-6596/558/1/012012

来源: IOP

【 摘 要 】

The atmospheric pressure mass spectrometric detection efficiency of organic species (tofisopam and verapamil) was measured by means of the laser ablation of dried solution drops containing known amount of the analyte. Ablated molecules were ionized by an atmospheric pressure laser plasma cell and then introduced in the TOF mass-spectrometer. The spot was formed by dripping 2 μl of solution on the stainless steel substrate and consequent drying. Then it was scanned by an intense ablating beam of various lasers (CO2, Nd:YAG and femtosecond fiber laser) until the spot was completely eroded during the non-stop MS-analysis of ablated material. The sensitivity was defined as the ratio of the total ion current integral of the relevant mass peaks to the amount of molecules in the spot. All the tested lasers are suitable for the ablation and subsequent MS-detection of organic species in dried solution spots given enough power deposition is provided. The measured sensitivity values reach 0.1 ions/fg of tested analytes.