On ripples and rafts: Curvature induced nanoscale structures in lipid membranes

7th Brazilian Meeting on Simulational Physics

Schmid, Friederike^1 ; Dolezel, Stefan^1 ; Lenz, Olaf^2 ; Meinhardt, Sebastian^1

Institut für Physik, Johannes Gutenberg-Universität Mainz, Germany^1

ICP, Universität Stuttgart, Germany^2

关键词: Coarse grained models;    Elastic modeling;    Elastic theory;    Lipid membranes;    Lipid raft;    Multicomponents;    Nanoscale structure;    Spontaneous formation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/487/1/012004/pdf
DOI  :  10.1088/1742-6596/487/1/012004

来源: IOP

【 摘 要 】

We develop an elastic theory that predicts the spontaneous formation of nanoscale structures in lipid bilayers which locally phase separate between two phases with different spontaneous monolayer curvature. The theory rationalizes in a unified manner the observation of a variety of nanoscale structures in lipid membranes: Rippled states in one-component membranes, lipid rafts in multicomponent membranes. Furthermore, we report on recent observations of rippled states and rafts in simulations of a simple coarse-grained model for lipid bilayers, which are compatible with experimental observations and with our elastic model.