The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix

Cellular & Molecular Biology Letters

Takhir Aripov³  Maksim Ionov¹  Maria Bryszewska²  Ilnora Tukfatullina³  Nina Baram³  Bakhtiyar Salakhutdinov³ 

[1] A.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan$$Department of General Biophysics, University of Łódź, Łódź, Poland$$;Department of General Biophysics, University of Łódź, Łódź, Poland$$;A.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan$$

关键词: Gossypol and its derivatives;    Lipid membranes;    Differential scanning calorimetry;    Membrane fluidity;   

DOI  :  10.2478/s11658-009-0037-x

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the incident radiation caused by the action of the polyphenol on the artificial membrane lipid matrix.

【 授权许可】

Unknown