The study of N-isopropylacrylamide gel dosimeter doped iodinated contrast agents

7th International Conference on 3D Radiation Dosimetry

Chang, Y.J.^1,2 ; Hsieh, L.L.^3 ; Liu, M.H.^3 ; Liu, J.S.^4 ; Hsieh, B.T.^3

Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology, Taichung, Taiwan^1

Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan^2

Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan^3

Tungs' Taichung MetroHarbor Hospital, Department of Diagnostic Radiology, Taichung, Taiwan^4

关键词: Iodinated contrast agents;    Iodinated contrast medium;    Methylene bisacrylamide;    N- isopropylacrylamide;    N-Isopropylacrylamide gels;    N-isopropylacrylamides;    Radiation sensitizers;    Radiosensitizers;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/444/1/012109/pdf
DOI  :  10.1088/1742-6596/444/1/012109

来源: IOP

【 摘 要 】

Low toxicity of N-isopropylacrylamide (NIPAM) dosimeter was doped with clinical iodinated contrast medium agents(Iobitridol (Xenetix® 350) and organically bound iodine (Conray® 60) as radiation sensitizers; The suitable gel dosimeter preparation formula in this research was 5 w/w% gelatin, 5 w/w% N-isopropylacrylamide, 3 w/w% N,N-methylene-bis-acrylamide, and 5 mM Tetrakis phosphonium chloride. The spiral CT was irradiator, and 120 kVp was the operating tube voltage. The maximum radiation dose was 0.6 Gy, and optical CT was the gel measurement device used. The results showed SERs with the addition of radiosensitizers were 10.70 (Xenetix® 350) and 9.67 (Conray® 60), respectively. Thus, the polymerized gel dosimeter could be used in the efficacy evaluation of low-energy and low-radiation dose.