Dosimetry for audit and clinical trials: challenges and requirements

7th International Conference on 3D Radiation Dosimetry

Kron, T.^1 ; Haworth, A.^1 ; Williams, I.^1

not available^1

关键词: Anthropomorphic phantoms;    Clinical trial;    Intensity-modulated radiation therapy;    Motion management;    Radiotherapy planning;    Reference points;    Treatment plans;    Volumetric modulated arc therapy;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/444/1/012014/pdf
DOI  :  10.1088/1742-6596/444/1/012014

来源: IOP

【 摘 要 】

Many important dosimetry audit networks for radiotherapy have their roots in clinical trial quality assurance (QA). In both scenarios it is essential to test two issues: does the treatment plan conform with the clinical requirements and is the plan a reasonable representation of what is actually delivered to a patient throughout their course of treatment. Part of a sound quality program would be an external audit of these issues with verification of the equivalence of plan and treatment typically referred to as a dosimetry audit. The increasing complexity of radiotherapy planning and delivery makes audits challenging. While verification of absolute dose delivered at a reference point was the standard of external dosimetry audits two decades ago this is often deemed inadequate for verification of treatment approaches such as Intensity Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT). As such, most dosimetry audit networks have successfully introduced more complex tests of dose delivery using anthropomorphic phantoms that can be imaged, planned and treated as a patient would. The new challenge is to adapt this approach to ever more diversified radiotherapy procedures with image guided/adaptive radiotherapy, motion management and brachytherapy being the focus of current research.