Antidiabetic potential of Caesalpinia sumatrana, a medicinal herbs traditionally used by local tribe in East Kalimantan

1st International Conference on Tropical Studies and Its Application

Wicaksono, D.A.^1 ; Rosamah, E.^1 ; Kusuma, I.W.^1

Faculty of Forestry, Mulawarman University, Jl. Ki Hajar Dewantara, East Kalimantan, Samarinda

75119, Indonesia^1

关键词: 1 ,1-diphenyl-2-picrylhydrazyl;    Alpha glucosidase;    Anti-oxidant activities;    Antioxidant capacity;    Ethanol extract;    Glucosidase activity;    Medicinal herb;    Phytochemicals;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/144/1/012027/pdf
DOI  :  10.1088/1755-1315/144/1/012027

来源: IOP

【 摘 要 】

The aims of the research was to analyze the content of phytochemicals, to examine the antioxidant and antidiabeticpotentials of n-hexane, chloroform, ethyl acetate, and ethanol extracts of Caesalpinia sumatrana. Method to measure antioxidant capacity of sample involves the use of the free radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH) which is widely used to test the ability of compounds to act as free radical. Analysis the potential of antidiabeticactivity of the extracts was determined by α-glucosidase and α-amylase inhibitory assay. Of all extracts obtained by successive maceration, ethanol maceration gave the highest extract by 2.63% of extract on the dry weigh basis. The result of phytochemicals showed that all extracts contain alkaloid and flavonoid. The highest antioxidant activity was 82.32% with IC50value of 5.00 μg/ml obtained by ethanol extract. The results of enzyme inhibitory assay of α-glucosidase showed that ethanol extract of C. sumatrana had IC50value 17.16 μg/mL to inhibit -glucosidase activity and IC50value 16.78 μg/mL for -amylase. The present result displayed potential of the plant to be developed as natural antidiabetic and antioxidant agents.