Transforming growth factor expression (TGF-β) correlate with serum level of malondialdehyde (MDA) after EVOO administration in preclinical rat models of preeclampsia

3rd International Conference on Biological Sciences and Biotechnology

Ilyas, Syafruddin^1,2 ; Hutahaean, Salomo^1 ; Irianti, Dan Evi^1

Departement of Biology, Faculty Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Kampus USU, Jl. Bioteknologi No. 1, Padang Bulan, Medan, Indonesia^1

Featured Center for Science and Technology Stem Cell, Universitas Sumatera Utara, Kampus USU, Medan. Dr. Masyur Street, No. 4, Padang Bulan, Medan, Indonesia^2

关键词: Malondialdehyde;    Negative control;    Randomized design;    Reactive Oxygene Species (ROS);    Second group;    Serum levels;    Transforming growth factors;    Treatment group;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/130/1/012048/pdf
DOI  :  10.1088/1755-1315/130/1/012048

来源: IOP

【 摘 要 】

Preeclampsia can cause cell death either apoptosis or necrosis. One cause is the disturbance of the emergence of malondialdehyde (MDA). Very few reports on the role of Transforming Growth Factor Expression (TGF-β) in the remodeling process of placental cells and their association with serum MDA content. Research of true experiment with complete randomized design (CRD) with five treatment groups. The first group, preeclampsia negative control (T0). The second group, preeclamptic rats model (T1). The third group, preeclamptic rats model+EVOO 0.45g/kg-Body Weight/day (T2). The fourth group, preeclamptic rats model+EVOO 0.90g/kg-BW/day (T3). The fifth group, preeclamptic rats model+EVOO 1.8 g/kg-BW/day (T4). The results showed a significant effect of EVOO on TGF-β expression in preeclampsia rats, meaning that there was a role of TGF-β against pre-eclampsia placenta remodeling. There was a positive and strong relationship (r=0.494) as well as a very significant relationship (p