Black Rice Potential in HDL and LDL Profile in Sprague Dawley Rat with High Cholesterol Diet

International Conference on Food Science and Technology

Nurhidajah^1 ; Astuti, R.^2 ; Nurrahman^1

Faculty of Nursing and Health Sciences, Jl. Kedungmundu Raya No 18, Semarang

50273, Indonesia^1

Faculty of Public Health University of Muhammadiyah Semarang, Jl. Kedungmundu Raya No 18, Semarang

50273, Indonesia^2

关键词: Black rice;    Developed countries;    High cholesterols;    Hypercholesterol;    Inflammatory process;    Metabolic disorders;    Negative control;    Sprague-Dawley rats;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/292/1/012019/pdf
DOI  :  10.1088/1755-1315/292/1/012019

来源: IOP

【 摘 要 】

Atherosclerosis is a significouldt health problem in developed countries and is a major cause of morbidity and mortality, especially in developing countries. Metabolic disorders which include increased levels of LDL and lipoprotein and decreased levels of HDL could cause atherosclerosis which is an inflammatory process due to the formation of plaques on the large artery walls. Black rice is a source of dietary fiber and anthocyanin could act as an antioxidant, which if consumed regularly could improve lipid profiles and blood antioxidants. This is expected to reduce the rate of disease caused by atherosclerosis. The purpose of this study to determine the potential of black rice on HDL and LDL levels in Sprague dawley mice with a high cholesterol diet. This study was in vivo experimental in Sprague dawley rats with a randomized post-test only control group design using 4 groups of rats weighing 175-200g. The group consisted of negative controls, positive controls, simvastatin and black rice drugs. The results showed that rats with hypercholesterol diet which were intervened with black rice feed for 12 weeks decreased LDL and increased HDL. Statistical tests showed that there was a significouldt effect between the treatment of feed on HDL and LDL levels. Further tests showed differences in each group. Conclusion of this study is black rice consumption could regulate lipid profiles by lowering LDL, increasing HDL levels and inhibiting the increase in fat oxidation results in the body with the MDA indicator.