Serum TNF-α levels and Helicobacter pylori cagA and vacA genes

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Siregar, G.A.^1 ; Halim, S.^1 ; Sitepu, R.R.^1 ; Darmadi^1

Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia^1

关键词: Cross-sectional study;    Helicobacter pylori;    Host defense;    Serum levels;    Serum samples;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012044/pdf
DOI  :  10.1088/1755-1315/125/1/012044

来源: IOP

【 摘 要 】

Helicobacter pylori is associated with higher virulence. TNF-α has an important role in host defense against H. pylori infection. The aim of this study was to investigate the relationship between TNF-α serum levels with cagA and vacA genes in H. pylori infection. This was a cross-sectional study involving 80 patients that consecutively admitted to endoscopy unit. Diagnosis of H. pylori infection was based on rapid urease test. Serum samples werecollected to determine circulating TNF-α level. Polymerase chain reaction was done to examine H. pylori vacA and cagA genes. Data analysis was carriedout using SPSS version 22 with 95%CI and p