Survival of HIV/AIDS patients with antiretroviral therapy in association with first-line regimens from 2007 _ 2010 in Haji AdamMalik general hospital Medan

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Kembaren, T.^1 ; Ginting, Y.^1 ; Saragih, R.H.^1

Division of Infectious and Tropical Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

关键词: Antiretroviral drugs;    Antiretrovirals;    General hospitals;    Indonesians;    Infected patients;    Side effect;    Stavudine;    Survival rate;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012026/pdf
DOI  :  10.1088/1755-1315/125/1/012026

来源: IOP

【 摘 要 】

The mortality related to AIDS have decreased dramatically among HIV infected patients taking HAART. HAART is the combination of at least 3 antiretroviral drugs based on the recommendation of WHO. The recent guideline for 1stline therapy recommended by the Indonesian Ministry of Health was Zidovudine/Lamivudine/Nevirapine (ZDV+3TC+NVP), Zidovudine/Lamivudine/Efavirenz (ZDV+3TC+EFV), Stavudine/Lamivudine/Nevirapine (d4T+3TC+NVP), Stavudine/Lamivudine/Efavirenz (d4T+3TC+EFV). Due to a side effect of Stavudine, Ministry of Health plan to pass out Stavudin from the regimens for 1stline therapy.We wanted to evaluate the survival of HIV/AIDS patients with first-line regimens in HAM general hospital Medan. A cohort retrospective study was conducted to evaluate the survival of HIV/AIDS patients taking a combination of 1stline antiretroviral therapy between January 2007 and December 2010. From 2007-2010, among 609 HIV/AIDS patients with first-line ARV medication, 77.5% were male, and 22.5% were female. The most common risk infection was heterosexual. The majority of the patients were in 25-34 years old group. Most of the patients with CD4 1-50 cell/mm3. 2 years survival rate in HIV/AIDS patients taking ZDV+3TC+NVP, ZDV+3TC+EFV, d4T+3TC+NVP, d4T+3TC+EFV were 61.5%, 61.2%, 57.5% and 59.3% respectively. There were no significant differences of 24 months survival in both regiment with or without d4T, 61.8% vs 63.6%.