Synthesis of 8-(2-fluoro-4-nitrophenoxy)-[1,2,4] triazolo [4,3-a] pyrazine

2018 4th International Conference on Environmental Science and Material Application

生态环境科学;材料科学

Zhang, Qian^1 ; Liu, Xiaobo^1 ; Zhang, Binliang^1 ; Tan, Lihong^1 ; Zheng, Pengwu^1

School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang

330013, China^1

关键词: Biologically active compounds;    Pyrazines;    Synthetic methods;    Total yield;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/252/2/022088/pdf
DOI  :  10.1088/1755-1315/252/2/022088

来源: IOP

【 摘 要 】

8-(2-fluoro-4-nitrophenoxy)-[1,2,4] triazolo [4,3-a] pyrazine (1) is an important intermediate in many biologically active compounds. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 2,3-dichloropyrazine (5) through three steps including substitution reaction and ring buckling reaction. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 80.04%.