Stopping the biological clock Merging biology and cryogenics in applied cryobiology

27th International Cryogenics Engineering Conference and International Cryogenic Materials Conference 2018

Getreu, N.^1^2 ; Fuller, B.^2

UCL Institute for Women's Health, 84-86 Chenies Mews, Bloomsbury London

WC1E 6HU, United Kingdom^1

Division of Surgery and Interventional Science, Centre for Surgical Innovation, Organ Repair and Transplantation, UCL Medical School and Royal Free London NHS Trust, London

NW3 2QG, United Kingdom^2

关键词: Biological clock;    Cellular activities;    Cryo-preservation;    Functional recovery;    Historical development;    On demands;    Scientific principles;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/502/1/012003/pdf
DOI  :  10.1088/1757-899X/502/1/012003

来源: IOP

【 摘 要 】

The ability to stop all cellular activity for a prolonged period of time, yet still be able to deliver functional recovery on demand, is the practical output of the science of cryobiology. This cessation of biological time allows cells to be preserved for months or years in medicine and biotechnology. This review discusses the historical development of cryobiology, the basic scientific principles underpinning cryopreservation, and how the technologies are currently used.