Heat shock protein 70/alpha-fetoprotein epitope peptide induced specific immunity against hepatocarcinoma

2nd International Symposium on Application of Materials Science and Energy Materials

材料科学;能源学

Xu, Bing^1 ; Wang, Xiaoping^1 ; Ma, Xiaojun^1 ; Lin, Huanping^1

School of Shaanxi University of Chinese Medicine, Xian, China^1

关键词: Alphafetoprotein (AFP);    Antitumor immunity;    Epitope peptide;    Heat shock protein;    Heat shock protein 70;    Hepatocarcinoma;    Hepatoma cells;    Peptide complex;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/490/6/062020/pdf
DOI  :  10.1088/1757-899X/490/6/062020

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

To study anti-tumor immunity mechanism induced by a reconstructed peptide complex-heat shock protein 70 (HSP70) and alphafetop-rotein (AFP), Mic e were immunized with AFP peptide, HSP70 and HSP70-AFP peptide complex es respectively. The killing effects of IFN-γ, TNF-α, perforin, granzyme B and CD8+ T cells on H22 cells were detected in each group of CD8+ T cell culture supernatants and investigate theimmune effect of heat shock protein 70 (HSP70)-alpha-fetoprotein (AFP)epitope peptide complex on mouse H22 hepatoma cells.