The urgency of finding therapeutic solutions for emerging and existing health challenges has never been more pronounced. In the pursuit of this goal, the value of a strategy that makes use of existing resources is being recognized: drug repurposing or repositioning of compounds for new indications. Such approaches are employed against cancer, rheumatoid arthritis, multiple sclerosis, HIV/AIDS, and many other diseases. This Collection, aptly titled “Drug Repurposing”, includes research and perspectives from scientists at the forefront of this innovative field.

Pressure, as one of the fundamental thermodynamic parameters, can profoundly change the interatomic distances, electronic interactions, chemical bonding and crystal structures, leading to exotic structures and properties of materials. High-pressure techniques have significantly impacted disciplines like physics, chemistry, geology, and life science, creating new materials, advancing knowledge of Earth's interior, and influencing pharmaceutical development. This editorial reviews the latest research published in this Collection, highlighting the potential of high-pressure studies to further our understanding of materials’ behavior under extreme conditions.

Adult neurogenesis supports important brain functions, such as learning and memory, and its decrease during aging may contribute to the cognitive decline of the aged brain. This Collection provides insight into the role, regulation, and age-associated reduction of adult neurogenesis, by gathering studies investigating this process in different model systems, ages, and brain regions.