3D genome organization

Scientific Reports

Editorial

Joanna M. Bridger¹  Asli Silahtaroglu²  Elissa P. Lei³ 

[1] Centre of Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, London, UK;Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;Nuclear Organization and Gene Expression Section, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA;

DOI  :  10.1038/s41598-022-26725-7

来源: Springer

【 摘 要 】

Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great effort has been made to understand the intricacies of 3D genome organization and its relevance to genomic and nuclear function. Over the years, many concepts, mathematical models, visual and biochemical methods, and analysis pipelines have been presented to study various aspects of this organization in a multidisciplinary manner, such as is also reflected within this collection.

【 授权许可】

CC BY   
© The Author(s) 2022