• 已选条件：
  • × Hazem A. Ghabbour
  • × 期刊论文
  • × Molecules
  • × 2015
 全选  【符合条件的数据共：9条】

1 An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction [期刊论文]

Molecules,2015年

Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, J. Carlos Menéndez, Mujeeb A. Sultan, Usama Karama, Hazem A. Ghabbour, Hoong-Kun Fun

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2 Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions [期刊论文]

Molecules,2015年

El Sayed H. El Ashry, Yeldez El Kilany, Nariman M. Nahas, Assem Barakat, Nadia Al-Qurashi, Hazem A. Ghabbour, Hoong-Kun Fun

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3 A Novel One-Pot Green Synthesis of Dispirooxindolo-pyrrolidines via1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides [期刊论文]

Molecules,2015年

Abdulrahman I. Almansour, Natarajan Arumugam, Raju Suresh Kumar, Govindasami Periyasami, Hazem A. Ghabbour, Hoong-Kun Fun

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4 Synthesis, Molecular Structure and Spectroscopic Investigations of Novel Fluorinated Spiro Heterocycles [期刊论文]

Molecules,2015年

Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Assem Barakat, Saied M. Soliman, Hazem A. Ghabbour, Ching Kheng Quah, Hoong-Kun Fun, Richard A. Bunce, Philippe Belmont, Wim Dehaen

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5 Synthesis, Characterization, and Anti-Cancer Activity of Some New N′-(2-Oxoindolin-3-ylidene)-2-propylpentanehydrazide-hydrazones Derivatives [期刊论文]

Molecules,,202015年

Ayman El-Faham, Sherine N. Khattab, Hazem A. Ghabbour, Hoong-Kun Fun, Muhammad Farooq, Mohammad A. Wadaan, Nael Abutaha

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Eight novel N′-(2-oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone derivatives 4a–h were synthesized and fully characterized by IR, NMR (1H-NMR and13C-NMR), elemental analysis, and X-ray crystallography. The cyto-toxicity and in vitro anti-cancer evaluation of the prepared compounds have been assessed against two different human tumour cell lines including human liver (HepG2) and leukaemia (Jurkat), as well as in normal cell lines derived from human embryonic kidney (HEK293) using MTT assay. The compounds 3e, 3f, 4a, 4c, and 4e revealed promising anti-cancer activities in tested human tumour cells lines (IC50 values between 3 and 7 μM) as compared to the known anti-cancer drug 5-Fluorouracil (IC50 32–50 μM). Among the tested compounds, 4a showed specificity against leukaemia (Jurkat) cells, with an IC50 value of 3.14 μM, but this compound was inactive in liver cancer and normal cell lines.

    6 Docking and Antiherpetic Activity of 2-Aminobenzo[de]-isoquinoline-1,3-diones [期刊论文]

    Molecules,2015年

    Rashad Al-Salahi, Ibrahim Alswaidan, Hazem A. Ghabbour, Essam Ezzeldin, Mahmoud Elaasser, Mohamed Marzouk

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