The atmospheric products of the Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm include column water vapor (CWV) at a 1 km resolution, derived from daily overpasses of NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) instruments aboard the Aqua and Terra satellites. We have recently shown that machine learning using extreme gradient boosting (XGBoost) can improve the estimation of MAIAC aerosol optical depth (AOD). Although MAIAC CWV is generally well validated (Pearson's R > 0.97 versus CWV from AERONET sun photometers), it has not yet been assessed whether machine-learning approaches can further improve CWV. Using a novel spatiotemporal cross-validation approach to avoid overfitting, our XGBoost model, with nine features derived from land use terms, date, and ancillary variables from the MAIAC retrieval, quantifies and can correct a substantial portion of measurement error relative to collocated measurements at AERONET sites (26.9 % and 16.5 % decrease in root mean square error (RMSE) for Terra and Aqua datasets, respectively) in the Northeastern USA, 2000–2015. We use machine-learning interpretation tools to illustrate complex patterns of measurement error and describe a positive bias in MAIAC Terra CWV worsening in recent summertime conditions. We validate our predictive model on MAIAC CWV estimates at independent stations from the SuomiNet GPS network where our corrections decrease the RMSE by 19.7 % and 9.5 % for Terra and Aqua MAIAC CWV. Empirically correcting for measurement error with machine-learning algorithms is a postprocessing opportunity to improve satellite-derived CWV data for Earth science and remote sensing applications.

The calibration microwave radiometer (CMR) on board the Haiyang-2A (HY-2A) satellite provides wet tropospheric delay correction for altimetry data, which can also contribute to the understanding of climate system and weather processes. The ground-based global navigation satellite system (GNSS) provides precise precipitable water vapor (PWV) with high temporal resolution and could be used for calibration and monitoring of the CMR data, and shipborne GNSS provides accurate PWV over open oceans, which can be directly compared with uncontaminated CMR data. In this study, the HY-2A CMR water vapor product is validated using ground-based GNSS observations of 100 International GNSS Service (IGS) stations along the global coastline and 56 d shipborne GNSS observations over the Indian Ocean. The processing strategy for GNSS data and CMR data is discussed in detail. Special efforts were made in the quality control and reconstruction of contaminated CMR data. The validation result shows that HY-2A CMR PWV agrees well with ground-based GNSS PWV with 2.67 mm as the root mean square (rms) within 100 km. Geographically, the rms is 1.12 mm in the polar region and 2.78 mm elsewhere. The PWV agreement between HY-2A and shipborne GNSS shows a significant correlation with the distance between the ship and the satellite footprint, with an rms of 1.57 mm for the distance threshold of 100 km. Ground-based GNSS and shipborne GNSS agree with HY-2A CMR well.

Background: Pre-symptomatic transmission can be a key determinant of the effectiveness of containment and mitigation strategies for infectious diseases, particularly if interventions rely on syndromic case finding. For COVID-19, infections in the absence of apparent symptoms have been reported frequently alongside circumstantial evidence for asymptomatic or pre-symptomatic transmission. We estimated the potential contribution of pre-symptomatic cases to COVID-19 transmission.Methods: Using the probability for symptom onset on a given day inferred from the incubation period, we attributed the serial interval reported from Shenzen, China, into likely pre-symptomatic and symptomatic transmission. We used the serial interval derived for cases isolated more than 6 days after symptom onset as the no active case finding scenario and the unrestricted serial interval as the active case finding scenario. We reported the estimate assuming no correlation between the incubation period and the serial interval alongside a range indicating alternative assumptions of positive and negative correlation.Results: We estimated that 23% (range accounting for correlation: 12 – 28%) of transmissions in Shenzen may have originated from pre-symptomatic infections. Through accelerated case isolation following symptom onset, this percentage increased to 46% (21 – 46%), implying that about 35% of secondary infections among symptomatic cases have been prevented. These results were robust to using reported incubation periods and serial intervals from other settings.Conclusions: Pre-symptomatic transmission may be essential to consider for containment and mitigation strategies for COVID-19.

We estimate the number of COVID-19 cases from newly reported deaths in a population without previous reports. Our results suggest that by the time a single death occurs, hundreds to thousands of cases are likely to be present in that population. This suggests containment via contact tracing will be challenging at this point, and other response strategies should be considered. Our approach is implemented in a publicly available, user-friendly, online tool.

Background: Several non-pharmaceutical interventions (NPIs) have been implemented across the world to control the coronavirus disease (COVID-19) pandemic. Social distancing (SD) interventions applied so far have included school closures, remote working and quarantine. These measures have been shown to have large impacts on pandemic influenza transmission. However, there has been comparatively little examination of such measures for COVID-19.Methods: We examined the existing literature, and collated data, on implementation of NPIs to examine their effects on the COVID-19 pandemic so far. Data on NPIs were collected from official government websites as well as from media sources.Results: Measures such as travel restrictions have been implemented in multiple countries and appears to have slowed the geographic spread of COVID-19 and reduced initial case numbers. We find that, due to the relatively sparse information on the differences with and without interventions, it is difficult to quantitatively assess the efficacy of many interventions. Similarly, whilst the comparison to other pandemic diseases such as influenza can be helpful, there are key differences that could affect the efficacy of similar NPIs.Conclusions: The timely implementation of control measures is key to their success and must strike a balance between early enough application to reduce the peak of the epidemic and ensuring that they can be feasibly maintained for an appropriate duration. Such measures can have large societal impacts and they need to be appropriately justified to the population. As the pandemic of COVID-19 progresses, quantifying the impact of interventions will be a vital consideration for the appropriate use of mitigation strategies.

Bletilla striata belongs to the family Orchidaceae , and it is mainly distributed in East Asia. The tubers of B. striata have been utilized in Traditional Chinese Medicine for various ailments, such as hematemesis, tuberculosis, malignant ulcers, hemorrhoids, traumatic bleeding, and chapped skin. Phytochemical investigation on B. striata has resulted in the identification of 192 monomeric compounds, including bibenzyls, phenanthrene derivatives, triterpenoids and its saponins, steroids and its saponins, malic acid derivatives, and anthocyanins. Moreover, B. striata polysaccharide is another typical chemical constituent of this plant. Pharmacology studies have shown that the plant possesses wound healing, antimicrobial, anticancer, antioxidative, and antiviral activities. This review aims to provide the latest and comprehensive information on chemical constituents, pharmacological activities, and quality control of B . striata and to identify future research needs.