• 已选条件：
  • × Lei Wang
  • × BMC Cancer
  • × 2010
 全选  【符合条件的数据共：2条】

1 Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients [期刊论文]

BMC Cancer,2010年

Guang He, Lin He, Zhihai Peng, Guoyin Feng, Yifeng Xu, Yanzeng Xiao, Jinfen Wang, Quan Wang, Fengping Yang, Jue Ji, Tao Li, Ti Wang, Peng Chen, Qingzhu Zhao, Baocheng Liu, Xingwang Li, Lei Wang, Yang Wang

英文

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Background

Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance.

Methods

To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.

Results

We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005.

Conclusions

Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.

    2 Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients [期刊论文]

    BMC Cancer,2010年

    Guang He, Lin He, Zhihai Peng, Guoyin Feng, Yifeng Xu, Yanzeng Xiao, Jinfen Wang, Quan Wang, Fengping Yang, Jue Ji, Tao Li, Ti Wang, Peng Chen, Qingzhu Zhao, Baocheng Liu, Xingwang Li, Lei Wang, Yang Wang

    英文

    预览  |  原文链接  |  全文  [ 浏览：1 下载：2  ]    

    Background

    Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance.

    Methods

    To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.

    Results

    We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005.

    Conclusions

    Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.