Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients

BMC Cancer

Yang Wang⁵  Lei Wang⁴  Xingwang Li⁵  Baocheng Liu⁵  Qingzhu Zhao⁵  Peng Chen⁵  Ti Wang⁵  Tao Li⁵  Jue Ji⁵  Fengping Yang⁵  Quan Wang¹  Jinfen Wang³  Yanzeng Xiao³  Yifeng Xu²  Guoyin Feng²  Zhihai Peng¹  Lin He⁵  Guang He⁵ 

[1] Department of General Surgery, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai 200080, China

[2] Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, China

[3] Shanxi Cancer Hospital, 3 Zhi Gong Xin Street, Taiyuan 320013, China

[4] Institutes of Biomedical Sciences Fudan University, 138 Yixueyuan Road, Shanghai 200032, China

[5] Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China

Others  :  1081308
DOI  :  10.1186/1471-2407-10-523

 received in 2010-05-27, accepted in 2010-10-04,  发布年份 2010

【 摘 要 】

Background

Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance.

Methods

To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.

Results

We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005.

Conclusions

Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.

【 授权许可】

   
2010 Wang et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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