I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles

Chemistry;Animal Physiology

Adams, Robert Train ; Niemann, Carl G. (advisor)

University:California Institute of Technology

Department:Chemistry and Chemical Engineering

关键词: Chemistry;    Animal Physiology;   

Others  :  https://thesis.library.caltech.edu/11770/2/Adams_RT_1950.pdf

美国|英语

来源: Caltech THESIS

【 摘 要 】

The preparation of each of the four optical isomers of α-amino-β-hydroxy-n-caproic acid is described. The configurations of the four optically active amino acids have been deduced on the basis of evidence obtained from the reactions of their N-benzoyl-O-methyl derivatives with p-toluidine in the presence of papain and evidence obtained by oxidative degradation of one of the active α-amino-β-hydroxy-n-caproic acids to an optically active α-hydroxyvaleric acid. The reduction of α-benzamido-β-methoxy-n-caproic acid with lithium aluminum hydride is described.

Experiments directed toward the synthesis of aminomethanesulfonamide and α-aminoethanesulfonamide are reported.

The influence of nerve impulse sequence on the contractions of different crustacean muscles has been investigated by studying the effect of intercalating extra stimuli during stimulation at a low frequency and by studying the effect of changes in the pattern of the stimulating impulses. The effect of impulse-spacing on subsequent facilitation of the contraction has been examined. The results of these investigations are described. The significance of pattern-sensitivity in synaptic structures is discussed.