Design and development of an elastin mimetic stent with therapeutic delivery potential

Rat stenting;Elastin miemtic;Laser fabrication;Crosslinking;Drug delivery;Stent

Martinez, Adam W. ; Biomedical Engineering

University:Georgia Institute of Technology

Department:Biomedical Engineering

关键词: Rat stenting;    Elastin miemtic;    Laser fabrication;    Crosslinking;    Drug delivery;    Stent;   

Others  :  https://smartech.gatech.edu/bitstream/1853/45926/1/martinez_adam_w_201112_phd.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

Stenting remains a common treatment option for atherosclerotic arteries. The main drawback of early stent platforms was restenosis, which has been combated by drug eluting stents; however, these stents have suffered from a higher incidence of late stage thrombosis. To address current stenting limitations, the major research focuses have been the development of the next generation of drug eluting stents and first generation bioabsorbable stents. The main objective of this dissertation was the design and development of a new class of bioabsorbable stent composed of elastin mimetic protein polymers. The first phase explored different stent design schemes and fabrication strategies. Successfully fabricated stents were then mechanically tested to ensure they possessed sufficient mechanical strength. Additionally, described herein is the potential to modulate the properties of the elastin mimetics through different crosslinking strategies. We have demonstrated that chemical crosslinking allows for the tailoring of the physical, mechanical, drug delivery, and endothelialization properties of these materials. The potential for drug delivery from this elastin mimetic stent was benchmarked as was the potential to endothelialize these stents. Furthermore, we developed the necessary delivery systems to allow for deployment in the rat aorta model.