Synthesis of functional polylactides for biomedical and pharmaceutical applications

Polylactide;Poly(lactic acid);Functional copolylactides;Antimicrobial copolylactide

Kalelkar, Pranav Pratap ; Collard, David M. Chemistry and Biochemistry France, Stefan Gutekunst, Will García, Andrés J. Oyelere, Adegboyega ; Collard, David M.

University:Georgia Institute of Technology

Department:Chemistry and Biochemistry

关键词: Polylactide;    Poly(lactic acid);    Functional copolylactides;    Antimicrobial copolylactide;   

Others  :  https://smartech.gatech.edu/bitstream/1853/62609/1/KALELKAR-DISSERTATION-2018.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

Polylactide (PL) is an aliphatic thermoplastic that has gained attention over the years as a result of it biocompatible and biodegradable behavior. These characteristics make PL an attractive material for use in biomedical devices and medical implants. However, the lack of functional groups along the backbone limits its applications. To overcome this limitation, I have synthesized five new functional copolylactides that bear reactive functional groups such as chloride, bromide, thiol, azide and electron-deficient alkenes. Incorporation of functional groups allow for post-polymerization modification using mild chemistry such as azide-alkyne click chemistry, thiol-ene click chemistry and atom-transfer radical polymerization. I have fabricated thin films and nanoparticles of selected materials to provide preliminary demonstration of these copolymers to bioconjugation, drug delivery and antimicrobial activity.