The Interaction of Boronic Acid Based Self-Assembled Monolayers as a Potential Glucose Sensor

biosensors;boronic acid;monolayers

Allen, Angela M. ; Christopher Gorman, Committee Chair,Charles B. Boss, Committee Member,Edmond F. Bowden, Committee Member,Kenneth W. Hanck, Committee Member,Allen, Angela M. ; Christopher Gorman ; Committee Chair ; Charles B. Boss ; Committee Member ; Edmond F. Bowden ; Committee Member ; Kenneth W. Hanck ; Committee Member

University:North Carolina State University

关键词: biosensors;    boronic acid;    monolayers;   

Others  :  https://repository.lib.ncsu.edu/bitstream/handle/1840.16/5801/etd.pdf?sequence=1&isAllowed=y

美国|英语

来源: null

【 摘 要 】

Recognition of sugars such as glucose with phenylboronic acid–terminated self assembled monolayers (SAMs) was the basis for the designing and fabricating a biosensor. Self-assembled monolayers were formed on gold surfaces as shown by infrared spectroscopy. The continuous, repeatable increase of the electrochemical impedance as the concentration of glucose was increased gave indication of binding. This binding could be attributed to the precedent formation of relatively stable esters between phenylboronic acids and sugars. This impedance change upon binding between glucose and a phenylboronic acid-terminated SAM showed promise in the development of a glucose biosensor.