Effects of neonatal capsaicin on formalin-induced ATF3 expression in the adult rat.

nociception;neonatal capsaicin;ATF3

Sarah Krupp

University:University of Louisville

Department:Anatomical Sciences and Neurobiology

关键词: nociception;    neonatal capsaicin;    ATF3;   

Others  :  https://ir.library.louisville.edu/cgi/viewcontent.cgi?article=3581&context=etd

美国|英语

来源: The Universite of Louisville's Institutional Repository

【 摘 要 】

Acute and chronic pain can be extremely debilitating conditions, and a better understanding of their underlying pathology is necessary to provide effective treatment. C-Fibers are responsible for transmission of the majority of nociceptive signals, with TRPV1+ C-Fibers being specific to noxious heat. Formalin, an inflammatory agent, acts through TRPA1+ C-Fibers, which have a high degree of co-localization with TRPV1. Using a neonatal capsaicin preparation, which irreversibly ablates the majority of TRPV1+ C-Fibers, formalin- induced inflammation and subsequent ATF3 expression was investigated. Results provide evidence that in addition to a lack of thermal nociception, animals treated with neonatal capsaicin had a lower threshold for mechanical nociception. Furthermore, neonatal capsaicin treatment reduced formalin- induced allodynia and prevented formalin-induced hyperalgesia. Lastly, treatment with neonatal capsaicin was shown to produce less small- diameter and more intermediate and large-diameter neurons in the DRG compared to vehicle-treated animals, as well as less overall ATF3 expression.