Investigation of age related changes to porcine cortical bone using nanoindentation and ash content

cortical bone;nanoindentation;ash content;scanning electron microscopy (SEM);stiffness;hardness;age;osteons;circumferential lamellae;interstitial lamellae;bone composition

Chittenden, Michael J. ; Jasiuk ; Iwona M.

关键词: cortical bone;    nanoindentation;    ash content;    scanning electron microscopy (SEM);    stiffness;    hardness;    age;    osteons;    circumferential lamellae;    interstitial lamellae;    bone composition;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/26284/Chittenden_Michael.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

This thesis focuses on the characterization of porcine cortical bone during its development stage.The goal of this research is to gain a further understanding of cortical bone, and to obtain data that can be used for inputs and validation of a computational model of cortical bone and individual bone lamella.The main technique used in this study is nanoindentation, and techniques such as scanning electron microscopy (SEM) and ash content test are used to find supplemental data.This thesis is comprised of two different parts, which are to be submitted as two different journal publications.The second part in the thesis is a joint paper written by myself and a previous graduate student.This study was performed prior to the main study in the thesis.The previous student completed the initial experiments and I completed the latter experiments, data analysis, and statistical analysis.This study uses nanoindentation to measure elastic modulus and hardness at the sub-microscale of the porcine cortical bone.The mechanical properties were analyzed as a function of age, orientation, bone structure, and hydration versus dehydration.The first study in the thesis is the main study.Once again, nanoindentation was utilized to measure the mechanical properties of porcine cortical bone.More age groups’ sub-microstructures were tested to obtain a more thorough analysis of the cortical bone development.The elastic modulus and hardness results were combined with quantitative data obtained from ash content tests to attain the relationship between composition and mechanical properties in the bone structures.Nanoindentation was combined with SEM to find the effect of local composition on the bone’s mechanical properties.