Strategies for developing ultrathin, high-density, actively multiplexed neural mapping device

flexible;neural;ultrathin;multiplexed;silk

Kim, Yun Soung ; Rogers ; John A.

关键词: flexible;    neural;    ultrathin;    multiplexed;    silk;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/31108/Kim_YunSoung.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Electronic systems that integrate with biological systems must be able to accommodate the dynamic mechanical characteristics of the tissue. With the rise in the interest of diagnosing and treating brain diseases it is critical that electrodes involving brain/machine interfaces have minimal effect on the brain while ensuring conformal coverage and good signal quality. A two-stage attempt is described in this thesis, where technological advancement involved in the producing of an extremely conformal platform is described, followed by the introduction of a high-density, actively multiplexed, flexible, and foldable sensor array. Experimental data show that as substrate thickness decreased the signal quality increased. Thin mesh-type systems showed further improvements in electrode response. An array of ultrathin, highly dense silicon nanomembrane transistors was fabricated on flexible plastic substrates and recorded neural activity with high spatial resolution. Brain activities, such as sleep spindles, single-trial visual evoked responses, and electrographic seizures could be successfully recorded. Analysis of the recorded data reveals the propagation of the punctual spatial patterns composed of planar and spiral waves during epileptic stage.