Worm-shaped polymersomes and their effects on targeting efficiency

particle shape

Choi, Je ; Kong ; Hyun Joon

关键词: particle shape;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/46914/Je_Choi.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow.