Customizable Intraoperative Neural Stimulator and Recording System for Deep Brain Stimulation Research and Surgery.

Deep Brain Stimulation Targeting System;Biomedical Engineering;Engineering;Biomedical Engineering

Dodani, SunjayAldridge, J. Wayne ;

University of Michigan

关键词: Deep Brain Stimulation Targeting System;    Biomedical Engineering;    Engineering;    Biomedical Engineering;   

Others  :  https://deepblue.lib.umich.edu/bitstream/handle/2027.42/99771/dodani_1.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Intraoperative targeting systems provide neurosurgeons with raw electrophysiological data through microelectrodes used for determining location in the brain.There are significant deficits to the available targeting systems, limiting the use in both clinical and research applications.The work presented in this dissertation is of the development and validation of an intraoperative neural stimulator and recording system for use in deep brain stimulation (DBS) surgeries.This intraoperative data acquisition system (IODA) was validated in three applications to ensure efficacy and improvements in research and clinical studies. The first application investigated was a clinical study illustrating the improvement IODA had on the targeting accuracy of DBS leads in the subthalamic nucleus (STN) over current targeting methods.It was demonstrated that the novel navigation algorithm developed for use with IODA targeted microelectrode probe locations significantly closer to final DBS lead positions compared to preoperatively planned trajectory positions.The second study investigated a clinical science application.There are considerable differences in recently published studies for the optimal chronic stimulation site in the STN region.It was shown, using beta oscillations of local field potentials (LFP) recorded by IODA, that optimal stimulation sites were significantly correlated with locations of peak beta activity when DBS leads were medial to the STN midpoint.While DBS lead trajectories lateral of the STN midpoint were significantly correlated with the dorsal border of the STN.The third study explored a basic science application involving the role of the STN in movement inhibition.Through wideband recordings made with IODA, it was shown that the STN is significantly activated during movement and movement inhibition cues as seen in the theta, alpha, and beta bands and single unit activity.Overall the results indicate the utility and adaptability of this system for use within DBS surgeries.There are many applications of IODA for use in research for other neurodegenerative disease including Essential Tremor and Depression.The use of this system has enables neurosurgeons to reduce surgical time, risk, and error for DBS procedures and made entry for those less experienced in this procedure easier.