A Model for Extraocular Fluid Dynamics

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Kakuji Tojo¹ 

[1] Department of Pharmaceutics, Controlled Drug-Delivery Research Center, College of Pharmacy, Rutgers, The State University of New Jersey

关键词: Biomedical Engineering;    Tear Flow Dynamics;    Ocular Drug Delivery;    Ocular Pharmacokinetics;    Topical Instillation;   

DOI  :  10.1252/jcej.22.518

来源: Maruzen Company Ltd

【 摘 要 】

References(21)Cited-By(2)A compartment model (side-capacity-parallel-flow model) is used to explain the extraocular fluid dynamics that affects markedly the bioavailability of drugs in ophthalmic delivery. The SCPF model well describes the clinical profile of drug concentration after topical application not only in the open eye with normal blinking but in the closed eye as well.

【 授权许可】

Unknown