This paper explores selected long-term sustainability issues related to increasing activities in outer space, with a particular focus on the economics of space debris. It reviews trends of selected space sustainability issues and discusses a range of possible policy actions. A notable policy response would be to strengthen space situational awareness systems and data reporting structures, while addressing operator compliance behaviour at both the national and international levels. Adequately addressing these challenges will require a reinforced coordinated international approach, in addition to increased collaboration with the private sector.