Many advanced nuclear reactor designs require new fuel, cladding, and structural materials. Data are needed to characterize the performance of these new materials in high temperature, oxidizing, and radiation conditions. To obtain this data, robust instrumentation is needed that can survive proposed test conditions. Standard thermocuoples for measuring temperature in-pile degrade at temperatures above 1100 degrees C. Hence, INL initiated a project to develop specialized thermocouples for high temperature in-pile applications. Results from efforts to develop, fabricate, and evaluate specialized high-temperature thermocouples for in-pile applications suggest that several material combinations are viable. Tests show that several low neutron cross-section candidate materials are resistant to material interactions and remain ductile at high temperatures.