Groundwater flow and transport predictions are a major component of remedial action evaluations for contaminated groundwater at the Savannah River Site. Because all groundwater modeling results are subject to uncertainty from various causes; quantification of the level of uncertainty in the modeling predictions is beneficial to project decision makers. Complex site-specific models present formidable challenges for implementing an uncertainty analysis. We present an overview of our experiences in conducting uncertainty analyses using the Monte Carlo method on two MODFLOW/MODPATH/MT3DMS groundwater flow and transport models in the reactor areas of the Savannah River Site.