The goal of this work is to establish basic data and techniques to enable safeguards appropriate to a new generation of nuclear power systems that will be based on fast spectrum reactors and mixed actinide fuels containing significant quantities of 'minor' actinides, possibly due to reprocessing, and determination of what new radiation signatures and parameters need to be considered. The research effort focuses on several problems associated with the use of fuel having significantly different actinide inventories that current practice and on the development of innovative techniques using new radiation signatures and other parameters useful for safeguards and monitoring. In addition, the development of new distinctive radiation signatures as an aid in controlling proliferation of nuclear materials has parallel applications to support Gen-IV and current advanced fuel cycle initiative (AFCI) goals as well as the anticipated Global Nuclear Energy Partnership (GNEP).