Initial- and final-state rescattering, neglected in the parton model, have a profound effect in QCD hard-scattering reactions, predicting single-spin asymmetries, diffractive deep inelastic scattering, diffractive hard hadronic reactions, the breakdown of the Lam Tung relation in Drell-Yan reactions, and nuclear shadowing and non-universalantishad owing--leading-twist physics not incorporated in the light-frontwavefunctions of the target computed in isolation. I also discuss the use of diffraction to materialize the Fock states of a hadronic projectile and test QCD color transparency, and anomalous heavy quark effects. The presence of direct higher-twist processes where a proton isproduced in the hard subprocess can explain the large proton-to-pion ratio seen in high centrality heavy ion collisions. I emphasize the importance of distinguishing between static observables such as the probability distributions computed from the square of the light-front wavefunctions versus dynamical observables which include the effects of rescattering.
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