Chemical and physical separations are critical to the Department of Energy's (DOE's) long-term efforts to cleanup in a cost-effective manner the environmental contamination and accumulated wastes in the nation's nuclear weapons complex and are incorporated into many baseline and alternate approaches. The purpose of this roadmap exercise was to provide a cohesive examination of the requirement for near- and long-term separations science and technology research to support implementation of baseline flow sheets for all sites as well as longer-term efforts to develop alternate flow sheets for the high-cost and/or high-risk projects. Alternatives that could provide major cost savings and acceleration of cleanup/closure schedules were also addressed. R&D efforts that existing at the close of FY2001 were examined to evaluate any gaps between the needs and the existing programs as well as opportunities that could result in major improvements in performance, costs, and/or schedules. The roadmap was assembled by the staff of the Efficient Separations and Processing Crosscutting Program, but it addressed needs and separations activities that were being pursued in other programs, including industrial contractors and university studies. Information for the roadmap was obtained from DOEEM organizations at all major sites, from focus areas, and from scientists who understood both the site needs and the potential technologies that could have a major impact in improving site and waste cleanup.