Within the Department of Energy's Office of Environmental Management (EM), the Office of Science and Technology (OST) identifies and develops innovative technologies that accelerate cleanup of highpriority environmental contamination problems and enable EM closure sites to meet closure schedules. OST manages an integrated research and development program that is essential to completing timely and cost-effective cleanup and stewardship of DOE sites. While innovative technologies can make significant contributions to the cleanup process, in some cases, EM has encountered unexpected barriers to their implementation. Technical obstacles are expected, but administrative challenges-such as regulatory, organizational, and stakeholder issues-must also be addressed. OST has found that collaborative needs identification and problem solving are essential components in overcoming these barriers. Collaboration helps EM meet its cleanup goals, close sites, and reduce the overall cost of cleanup at DOE sites nationwide. This paper presents examples of OST's collaboration efforts that expedite site closure and solve specific cleanup problems at EM sites.