Disclosed herein is a cryogenic heat transfer system capable of transferring 50 W or more at cryogenic temperatures of 100.degree. K or less for use with cryocooler systems. In an embodiment, a cryogenic heat transfer system comprises a refrigerant contained within an inner chamber bound by a condenser in fluid communication with an evaporator through at least one flexible conduit, the condenser in thermal communication with the cold station of a cryocooler, and the evaporator positionable in thermal communication with a heat source, typically a radiation shield of a cryogenic chamber. A process to remove heat from a cryogenic chamber is also disclosed.