Challenges in Clinical Management of Radiation-Induced Illnesses in Exploration Spaceflight

Blue, Rebecca ; Chancellor, Jeffery ; Suresh, Rahul ; Carnell, Lisa ; Reyes, David ; Nowadly, Craig ; Antonsen, Erik

关键词: RADIATION DOSAGE;    SIGNS AND SYMPTOMS;    SOLAR STORMS;    SOLAR CORPUSCULAR RADIATION;    SPACE EXPLORATION;    DEEP SPACE;    BIOASTRONAUTICS;    DESIGN ANALYSIS;    COAGULATION;    HEMATOPOIETIC SYSTEM;    INTRAVASCULAR SYSTEM;    ANIMAL MODELS;    MISSION PLANNING;   

RP-ID  :  JSC-CN-40647

学科分类：医学（综合）

美国|英语

来源: NASA Technical Reports Server

【 摘 要 】

Historical solar particle events (SPEs) provide context for some understanding of acute radiation exposure risk to astronauts traveling outside of low Earth orbit. Modeling of potential doses delivered to exploration crewmembers anticipates limited radiation-induced health impacts, including prodromal symptoms of nausea, emesis, and fatigue, but suggests that more severe clinical manifestations are unlikely. Recent large animal-model research in space-analogs closely mimicking SPEs has identified coagulopathic events independent of the hematopoietic sequelae of higher radiation doses, similar in manifestation to disseminated intravascular coagulation (DIC). We explored the challenges of clinical management of radiation-related clinical manifestations, using currently accepted modeling techniques and anticipated physiological sequelae, to identify medical capabilities needed to successfully manage SPE-induced radiation illnesses during exploration spaceflight.