Final project report

Hood, Nitin S. Baliga and Leroy

Institute for Systems Biology

关键词: 99 General And Miscellaneous//Mathematics, Computing, And Information Science;    Forecasting;    Genes;    59 Basic Biological Sciences;    Biology;   

DOI  :  10.2172/940834
RP-ID  :  DOE/ER/63807-3
RP-ID  :  FG02-04ER63807
RP-ID  :  940834

美国|英语

来源: UNT Digital Library

【 摘 要 】

The proposed overarching goal for this project was the following: Data integration, simulation and visualization will facilitate metabolic and regulatory network prediction, exploration, and formulation of hypotheses. We stated three specific aims to achieve the overarching goal of this project: (1) Integration of multiple levels of information such as mRNA and protein levels, predicted protein-protein interactions/associations and gene function will enable construction of models describing environmental response and dynamic behavior. (2) Flexible tools for network inference will accelerate our understanding of biological systems. (3) Flexible exploration and queries of model hypotheses will provide focus and reveal novel dependencies. The underlying philosophy of these proposed aims is that an iterative cycle of experiments, experimental design, and verification will lead to a comprehensive and predictive model that will shed light on systems level mechanisms involved in responses elicited by living systems upon sensing a change in their environment. In the previous years report we demonstrated considerable progress in development of data standards, regulatory network inference and data visualization and exploration. We are pleased to report that several manuscripts describing these procedures have been published in top international peer reviewed journals including Genome Biology, PNAS, and Cell. The abstracts of these manuscripts are given and they summarize our accomplishments in this project.